Transfusion
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Randomized Controlled Trial Multicenter Study
A multicenter pilot-randomized controlled trial of the feasibility of an augmented red blood cell transfusion strategy for patients treated with induction chemotherapy for acute leukemia or stem cell transplantation.
Anemia may be an important factor contributing to an increased risk of bleeding, particularly in patients with thrombocytopenia. ⋯ This pilot study thus indicated that it would be feasible to enroll the required number of patients to enable the performance of a large RCT to investigate the effect of Hb on bleeding risk in thrombocytopenic patients.
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Multicenter Study
Blood transfusions in children: a multi-institutional analysis of practices and complications.
Blood product transfusions are a valuable health-care resource. Guidelines for transfusion exist, but variability in their application, particularly in children, remains. The risk factors that threaten transfusion safety are well established, but because their occurrence in children is rare, single-institution studies have limited utility in determining the rates of occurrence. An epidemiologic approach that investigates blood transfusions in hospitalized children may help improve our understanding of transfused blood products in this vulnerable population. ⋯ The administration of blood products to children is a common practice in academic children's hospitals. Complications associated with these transfused products are rare.