Archives of neurology
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Archives of neurology · Nov 2008
ReviewReview of tissue plasminogen activator, ischemic stroke, and potential legal issues.
The use of tissue plasminogen activator in ischemic stroke is controversial. Many practicing physicians believe that its usefulness is established, while others, including professional specialty societies, are less sanguine. ⋯ These findings may implicate important potential legal issues. Informed consent concerns and, potentially, medical malpractice claims may result, particularly in the context of evidence-based practice, pay for performance, and the currently limited use of tissue plasminogen activator for eligible patients.
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Archives of neurology · Nov 2008
Predicting clinical progression in multiple sclerosis with the magnetic resonance disease severity scale.
Individual magnetic resonance imaging (MRI) disease severity measures, such as atrophy or lesions, show weak relationships to clinical status in patients with multiple sclerosis (MS). ⋯ Combining brain MRI lesion and atrophy measures can predict MS clinical progression and provides the basis for developing an MRI-based continuous scale as a marker of MS disease severity.