Archives of neurology
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Archives of neurology · Sep 2011
ReviewRisk factors and preventive interventions for Alzheimer disease: state of the science.
Numerous studies have investigated risk factors for Alzheimer disease (AD). However, at a recent National Institutes of Health State-of-the-Science Conference, an independent panel found insufficient evidence to support the association of any modifiable factor with risk of cognitive decline or AD. ⋯ Currently, insufficient evidence exists to draw firm conclusions on the association of any modifiable factors with risk of AD.
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Archives of neurology · Sep 2011
Comparative StudyComparison of analytical platforms for cerebrospinal fluid measures of β-amyloid 1-42, total tau, and p-tau181 for identifying Alzheimer disease amyloid plaque pathology.
Cerebrospinal fluid (CSF) biomarkers of Alzheimer disease (AD) are currently being considered for inclusion in revised diagnostic criteria for research and/or clinical purposes to increase the certainty of antemortem diagnosis. ⋯ The INNOTEST and INNO-BIA CSF platforms perform equally well in identifying individuals with underlying amyloid plaque pathology. Differences in absolute values, however, point to the need for assay-specific diagnostic cutoff values.
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Archives of neurology · Sep 2011
Comparative StudyClinical characterization of a kindred with a novel 12-octapeptide repeat insertion in the prion protein gene.
To report the clinical, electroencephalographic, and neuroradiologic findings in a kindred with a novel insertion in the prion protein gene, PRNP. ⋯ This kindred has a unique combination of clinical and neuropathologic features associated with the largest base pair insertion identified to date in PRNP and underscores the need to consider familial prion disease in the differential diagnosis of a familial frontotemporal dementia-like syndrome.
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Archives of neurology · Sep 2011
Biography Historical ArticleIn memoriam: John W. “Jack” Griffin, MD.