Archives of neurology
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Archives of neurology · May 2012
Autoimmune epilepsy: clinical characteristics and response to immunotherapy.
To describe clinical characteristics and immunotherapy responses in patients with autoimmune epilepsy. ⋯ When clinical and serological clues suggest an autoimmune basis for medically intractable epilepsy, early-initiated immunotherapy may improve seizure outcome.
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Archives of neurology · Mar 2012
ReviewThe evolution of academic neurology: new information will bring new meaning.
We are on the cusp of what promises to be an era of unprecedented progress in neurology. Even with current fiscal constraints and serious concerns about how health care will be organized and financed, in the next 2 decades progress in neurology and neurological science will create important new insights into understanding the brain as we decipher its disorders and discover and apply effective treatments.
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Archives of neurology · Mar 2012
ReviewClinical significance of rare copy number variations in epilepsy: a case-control survey using microarray-based comparative genomic hybridization.
To perform an extensive search for genomic rearrangements by microarray-based comparative genomic hybridization in patients with epilepsy. ⋯ Patients with epilepsy show a significantly increased burden of large, rare, gene-rich CNVs, particularly when associated with mental retardation and neuropsychiatric features. The limited overlap between CNVs observed in the epilepsy group and those observed in the group with mental retardation only as well as the involvement of specific (ion channel) genes indicate a specific association between the identified CNVs and epilepsy. Screening for CNVs should be performed for diagnostic purposes preferentially in patients with epilepsy and mental retardation or neuropsychiatric features.
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Archives of neurology · Feb 2012
Pattern classification of volitional functional magnetic resonance imaging responses in patients with severe brain injury.
Recent neuroimaging investigations have explored the use of mental imagery tasks as proxies for an overt motor response, in which patients are asked to imagine performing a task, such as "Imagine yourself swimming." ⋯ Pattern classification in functional magnetic resonance imaging is a promising technique for advancing the understanding of volitional brain responses in patients with severe brain injury and may serve as a powerful complement to traditional general linear model-based univariate analysis methods.