The primary care companion for CNS disorders
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Prim Care Companion CNS Disord · Feb 2018
ReviewActual Versus Expected Doses of Half Tablets Containing Prescribed Psychoactive Substances: A Systematic Review.
To assess through a systematic review of the literature if the practice of splitting tablets containing psychoactive/psychotropic medications for medical or economic reasons would result in the expected doses. ⋯ It cannot be generalized that splitting psychoactive drugs compromises dose accuracy, thus tablet splitting might still be employed in cases in which the advantages outweigh the disadvantages. It is recommended that alternatives be adopted to prevent the disadvantages related to tablet splitting.