Annals of palliative medicine
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Non-small cell lung cancer (NSCLC) is the most common and deadly malignancy in the United States. A significant portion of these individuals can present with or later develop metastatic NSCLC (mNSCLC). These patients typically do not survive more than two to three years after diagnosis despite the use of systemic therapies; however, there are individuals with low burden mNSCLC (oligometastatic disease) who can potentially be cured with the use of aggressive local therapies-such as stereotactic ablative radiotherapy (SAbR)-in conjunction with or without systemic therapy. ⋯ The combination of immunotherapy and SAbR likely represents one of the most effective while still tolerable therapies in this patient population. There are other subtypes of oligometastatic disease, including oligoprogressive disease which are amenable to SAbR. The current literature supports the use of SAbR in this population to increase the time of a patient's current systemic therapy; however, there are prospective studies evaluating the efficacy of treatment on progression free survival (PFS).
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When it comes to the treatment of aplastic anemia fever, the Guidelines for Aplastic Anemia regards Anti-thymocyte globulin (ATG) combined with eltrombopag as the standard immunosuppressive treatment plan, and ATG is the main mode to treat severe aplastic anemia. A large number of prospective studies and clinical trials have confirmed the clinical application value of eltrombopag in aplastic anemia. Although ATG combined with eltrombopag brings satisfactory treatment results, the safety of long-term use is still unclear. Therefore, more clinical trial studies are needed to verify its safety. ⋯ This meta-analysis demonstrated that the combination of ATG with eltrombopag in the treatment of SAA is safer and more effective than ATG alone.
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The effectiveness of Tai Chi for chronic obstructive pulmonary disease (COPD) so far is unclear. The present systematic review aimed to determine the influence of Tai Chi among people with COPD. ⋯ Tai Chi may have the potential to reduce dyspnoea, enhance exercise capacity, and improve the quality of life in COPD patients. People with COPD may obtain benefit from practicing Tai Chi.
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Aerobic exercise is currently considered to be an effective method of rehabilitation in breast cancer patients. Studies have shown that aerobic exercise after breast cancer surgery can improve upper limb function, cardiopulmonary function, and quality of life. Breast cancer rehabilitation guidelines encourage patients to actively participate in aerobic exercise to promote rehabilitation, the current study is to evaluate the effectiveness of aerobic exercise on upper limb muscle strength and range of motion (ROM) following breast cancer treatment. ⋯ Aerobic exercise could improve shoulder joint ROM in breast cancer survivors, but shows no obvious effect on the improvement of upper limb strength.
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Meta Analysis
Risk predictive models for delirium in the intensive care unit: a systematic review and meta-analysis.
An emerging approach to prevent delirium in an intensive care unit is the use of risk prediction models. At present, there is no scientific comparison of the predictive effect of the prediction model. This systematic review and meta-analysis aimed to compare the performance of available delirium risk prediction models for intensive care units. ⋯ The E-PRE-DELIRIC model, PRE-DELIRIC model, or both are recommended to predict ICU delirium risk. However, the recommendation should be considered with caution because of substantial heterogeneity. The protocol was registered with PROSPERO (CRD42019130802).