European journal of vascular surgery
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Randomized Controlled Trial Comparative Study Clinical Trial
Epidural anaesthesia prolonged into the postoperative period prevents stress response and platelet hyperaggregability after peripheral vascular surgery.
The occlusion rate of peripheral vascular grafts depends on technical as well as endogenous factors. Platelets play an integral part in graft failure and it has been suggested that anaesthesia may influence platelet function. In order to evaluate the influence of anaesthesia on stress response and platelet function in peripheral vascular surgery, patients (n = 18) were allocated to either general anaesthesia (GA; n = 9) followed by alleviation of postoperative pain with intramuscular analgesics or to lumbar epidural anaesthesia (EPI; n = 9) which was continued for 24 hours postoperatively. ⋯ Platelet aggregability was reduced intraoperatively in both groups but in the postoperative period there was a marked hyperaggregability only in the GA group. P-5HT was increased preoperatively in both groups but was not affected by surgery. It is concluded that epidural anaesthesia, due to its effects on platelet aggregability, may be advantageous for peripheral vascular surgery.
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Comparative Study
Prolonged postoperative myocardial ischaemia and infarction in vascular surgery performed under regional anaesthesia.
The importance of prolonged postoperative myocardial ischaemia in cardiac outcome has recently been emphasised. The present study examines the correlation between perioperative ischaemia and myocardial infarction (MI) in patients undergoing peripheral vascular surgery (PVS) under regional anaesthesia. One-hundred-and-forty consecutive peripheral vascular operations under regional anaesthesia were prospectively analysed, using Holter monitoring for perioperative myocardial ischaemia (defined as down sloping or horizontal ST-segment depression of > or = 1 mm) and postoperative cardiac outcome. ⋯ In 65 cases (46.4%) there were 259 episodes of significant ST-depression. In 75 (53.6%) cases ischaemic episodes were not detected. Patients with postoperative cardiac events had significantly more and longer ischaemic episodes in all three perioperative periods than those without such events.(ABSTRACT TRUNCATED AT 250 WORDS)
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Intraoperative Duplex examination can be used to identify technical imperfections during carotid endarterectomy. The objectives of this study were: (1) to evaluate the technical feasibility of intraoperative Duplex; (2) to compare Duplex findings with contrast arteriography; (3) to correlate intraoperative Duplex findings with postoperative complications and with Duplex data obtained during follow-up. ⋯ Duplex scanning is easy to use after completion of carotid endarterectomy. There is good agreement between intraoperative Duplex scanning and contrast arteriography. Extensive spectral broadening of the Doppler velocity signal is associated with an increased prevalence of early postoperative complications. Restenosis at follow-up appears to be related to severe flow disturbance as was demonstrated for the external carotid artery.