Indian journal of pediatrics
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Randomized Controlled Trial
Intravenous diazepam, midazolam and lorazepam in acute seizure control.
To evaluate the safety and efficacy of three benzodiazepine drugs: Lorazepam, Midazolam and Diazepam, when given parenterally in the control of acute seizure. ⋯ All the three groups were comparable in terms of time to clinical seizure cessation, seizure recurrence and uncontrolled seizures after drug administration. However, number of patients requiring second dose to control seizures were significantly higher in diazepam group when compared to lorazepam group. Excessive somnolence and sedation occurred more frequently with diazepam.
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Non traumatic coma in childhood is an important emergency. It can result from wide range of etiologies. CNS infections are the most common cause of non traumatic coma in children. ⋯ Management of a comatose child goes hand in hand with clinical evaluation. It is an emergency that requires simultaneous institution of immediate life support, identification of the cause and institution of definite therapy. The primary goal is to establish airway, breathing and circulation and to identify and treat raised intracranial pressure and seizures.