The Journal of the Kentucky Medical Association
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Although hypoxic-ischemic encephalopathy (HIE) is relatively rare, it commonly results in devastating long-term mortality and death. Intervention against this condition has been limited and frustrating. ⋯ Many questions, however, still remain unanswered about the use of hypothermia. Long-term efficacy and safety of hypothermia needs to be established before it can be recommended "as standard of care" for the treatment of neonatal HIE.