Progress in clinical and biological research
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A program of platelet cryopreservation has been developed at the Baltimore Cancer Research Center which now provides substantial proportion of the platelet transfusion requirements of alloimmunized patients. The program has gradually grown in size during the last eight years and in 1979 approximately 1600 units of frozen platelets were transfused including 225 transfusions of autologous platelets administered to 45 patients with leukemia. ⋯ Post-transfusion increments have been highly consistent during the last five years, averaging two thirds of the recovery obtained with fresh platelets with accompanying shortening of the bleeding time. The technology is simple, cost effective and reproducible and is suitable for use in more general blood bank settings.
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Prog. Clin. Biol. Res. · Jan 1982
ReviewAnimal research on hypovolemic shock and resuscitation: an update.
Animal studies have indicated that volume resuscitation is successful with salt-containing crystalloid solutions as well as colloid solutions. Hyperosmolar salt solutions appear to have benefits over isosmolar solutions. Both, however, produce hypoproteinemia, which can lead to edema formation due to changes in the transcapillary oncotic gradient and possibly by changing the interstitial matrix. ⋯ Colloid therapy, either proteins or dextran, effectively restores cardiovascular stability after hypovolemia and also prevents the increased transcapillary fluid flux seen in the lung and soft tissues, the former not appearing to be of much clinical significance, while the latter may lead to significant tissue edema. Blood replacement is necessary to restore adequate oxygen delivery to the tissues. The ideal hematocrit appears to be around 30-35.