Annals of burns and fire disasters
-
Ann Burns Fire Disasters · Mar 2018
Acute respiratory distress syndrome among severe burn patients in a developing country: application result of the berlin definition.
Our aim was to investigate risk factors and outcome of Acute Respiratory Distress Syndrome (ARDS) in severe burn patients. A descriptive study was carried out on 159 adult burn patients with burn extent ≥ 20% total body surface area, treated at the Burn Intensive Care Unit, National Institute of Burns. ARDS was defined according to the 2012 Berlin definition. ⋯ Severe ARDS was recorded in 30 of these patients, accounting for 66.7%. Inhalation injury, burn surface area over 40% and full thickness burn area over 20% TBSA were determined as risk factors for the development of ARDS. Mortality rate of patients with ARDS was extremely high (80%), especially for severe ARDS patients (p < 0.01), and deaths were mostly due to multiple organ failure.
-
Ann Burns Fire Disasters · Mar 2018
Shedding of the endothelial glycocalyx is quantitatively proportional to burn injury severity.
Limited information exists regarding endothelial dysfunction following burn injury. This project aims to evaluate whether thermal injury results in shedding of the endothelial glycocalyx in a manner quantitatively proportional to injury severity, and whether theloss of intact glycocalyx is measurable in end organs. C57BL/6 mice were grouped as uninjured controls, 10% or 25% Total Body Surface Area (TBSA) scald burns. ⋯ Similarly, there was less spleen syndecan-1 immunostaining in burned animals compared to controls at all time points. Burn injury causes shedding of syndecan-1 in a murine model, with levels correlated to injury severity and loss of the glycocalyx in lung and spleen. This work provides further insight into quantification and temporality of glycocalyx damage and systemic response to burn.