The European journal of surgery = Acta chirurgica
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Clinical Trial Controlled Clinical Trial
Dose response profiles of human growth hormone in subcutaneous wound chambers in rats.
To investigate dose response profiles of human growth hormone in soft connective tissue healing when it is given locally in subcutaneous wound chambers. ⋯ The clinical use of topical growth hormone in wound healing may be complicated by the relatively narrow therapeutic interval.
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To find out if intramedullary nailing affects lung function and microvascular permeability whether or not the lung is already injured; if so whether a different method of fixation would diminish the effect; and are the pathogenetic changes related to mechanisms known to precipitate adult respiratory distress syndrome? ⋯ Intramedullary nailing causes additional damage to lungs after lung damage and haemorrhagic shock in sheep. This can be avoided if (in the presence of additional injuries) alternative methods are used.