The European journal of surgery = Acta chirurgica
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It has been hypothesised that failure of the gut is an important pathophysiological phenomenon of the generalised inflammatory response that leads to the multiple organ dysfunction syndrome (MODS). Abnormal colonisation, infections of gut origin, bacterial translocation are all signs of gut failure that have been implicated in the pathogenesis of MODS. ⋯ In other patients, however, this relationship is not so clear and it seems that these phenomena may reflect a failure of the host's immune and mechanical defence systems and are epiphenoma of critical illness. The causal relation between those phenomena and the development of MODS are complex and need further clarification.
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Comparative Study
Effect of sodium nitroprusside on cerebral haemodynamics during cross-clamping of the descending thoracic aorta in pigs.
To assess the effect of sodium nitroprusside on cerebral haemodynamics during cross-clamping of the descending thoracic aorta in pigs. ⋯ Sodium nitroprusside did not affect intracerebral pressure, sagittal sinus pressure, or cerebral flux during cross-clamping of the descending thoracic aorta. Increased cerebral blood flow rather than venous congestion is the most likely cause of increased intracranial pressure during cross-clamping of the descending thoracic aorta.