The European journal of surgery = Acta chirurgica
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Randomized Controlled Trial Clinical Trial
Total mesorectal excision (TME) with or without preoperative radiotherapy in the treatment of primary rectal cancer. Prospective randomised trial with standard operative and histopathological techniques. Dutch ColoRectal Cancer Group.
To document local recurrence in primary rectal cancer when standardised techniques of surgery, radiotherapy, and pathology are used, and to investigate whether the local recurrence rate after total mesorectal excision permits the omission of adjuvant short term preoperative radiotherapy. ⋯ The accrual of our trial is going well and it is feasible; short term preoperative radiotherapy is safe even in combination with TME.
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To assess the morbidity and its main risk factors after major hepatic resection. ⋯ The morbidity associated with major hepatic resections remains high, and the main determinants of outcome are intraoperative surgeon-related factors.