The American journal of gastroenterology
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Am. J. Gastroenterol. · Jun 2000
Multicenter Study Comparative StudyAssessment of gastric emptying using a low fat meal: establishment of international control values.
The diagnosis of gastroparesis implies delayed gastric emptying. The diagnostic gold standard is scintigraphy, but techniques and measured endpoints vary widely among institutions. In this study, a simplified scintigraphic measurement of gastric emptying was compared to conventional gastric scintigraphic techniques and normal gastric emptying values defined in healthy subjects. ⋯ This multicenter study provides gastric emptying values in healthy subjects based on data obtained using a large sample size and consistent meal and methodology. Gastric retention of >10% at 4 h is indicative of delayed emptying, a value comparable to those provided by more intensive scanning approaches. Gastric emptying of a low fat meal is initially faster in men but is comparable in women at 4 h; it is also faster in older individuals but is independent of body mass.
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Am. J. Gastroenterol. · Jun 2000
Comparative Study Clinical Trial Controlled Clinical TrialPropofol versus midazolam and meperidine for conscious sedation in GI endoscopy.
Propofol (2,6-diisopropyl phenol) is a relatively new intravenous sedative hypnotic with an ideal pharmacokinetic profile for conscious sedation. In this study, we compared the safety and efficacy of propofol versus the conventional regimen of midazolam and meperidine for conscious sedation in GI endoscopy. ⋯ Propofol was associated with a statistically significant improvement in comfort and sedation score when compared to midazolam and meperidine.