The American journal of gastroenterology
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Am. J. Gastroenterol. · Aug 2002
Randomized Controlled Trial Comparative Study Clinical TrialSynergistic sedation with midazolam and propofol versus midazolam and pethidine in colonoscopies: a prospective, randomized study.
The aim of our study was to compare the safety and efficacy of the synergistic sedation with a low dose of midazolam combined with propofol versus the standard regimen of midazolam and pethidine for conscious sedation in colonoscopy in a group of patients that included a sufficient number of elderly patients with several comorbidities. ⋯ Our data suggest that the synergistic sedation with a low dose of midazolam combined with propofol was superior to a standard combination of midazolam and the opioid pethidine for colonoscopies as far as the patient comfort and recovery times are concerned.