The American journal of gastroenterology
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Am. J. Gastroenterol. · Mar 2005
Randomized Controlled Trial Comparative Study Clinical TrialAcute hemodynamic effects of octreotide and terlipressin in patients with cirrhosis: a randomized comparison.
Octreotide and terlipressin are widely used in acute variceal hemorrhage to reduce the bleeding rate. They purportedly act by mesenteric arterial vasoconstriction, thus reducing portal venous flow (PVF) and portal pressure. Little is known about the immediate-early hemodynamic effects of these drugs. ⋯ Octreotide only transiently reduced portal pressure and flow, whereas the effects of terlipressin were sustained. These results suggest that terlipressin may have more sustained hemodynamic effects in patients with bleeding varices.