The American journal of gastroenterology
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Am. J. Gastroenterol. · May 2015
Randomized Controlled Trial Multicenter StudyA randomized, placebo-controlled trial of lubiprostone for opioid-induced constipation in chronic noncancer pain.
This multicenter, phase 3 trial evaluated oral lubiprostone for constipation associated with non-methadone opioids in patients with chronic noncancer-related pain. ⋯ Lubiprostone significantly improved symptoms of OIC and was well tolerated in patients with chronic noncancer pain.