International journal of critical illness and injury science
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Int J Crit Illn Inj Sci · Jan 2018
Three- versus four-factor prothrombin complex concentrate for the reversal of warfarin-induced bleeding.
The objective of this study was to evaluate the effectiveness of 3-factor prothrombin complex concentrate (3F-PCC) compared to 4-factor PCC (4F-PCC) in warfarin-associated bleeding. ⋯ The use of 4F-PCC leads to a more significant reduction in INR compared to 3F-PCC though no difference in mortality or length of stay was observed. Thromboembolism rates were similar among both groups.