Arquivos brasileiros de cardiologia
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Arq. Bras. Cardiol. · Sep 2011
Randomized Controlled Trial Comparative StudyTrimetazidine on ischemic injury and reperfusion in coronary artery bypass grafting.
The ischemia and reperfusion ischemia is a common physiopathological mechanisms, which has difficult control during Coronary Artery Bypass Grafting (CABG) with cardiopulmonary bypass, the critical moment of which happening by the end of surgery, when there is declamping of aorta and release of hyperoxic radicals causing the injury. ⋯ Trimetazidine was effective in reducing ischemic injury and reperfusion, had no effect on left ventricular function, and no side effects were observed.