Arquivos brasileiros de cardiologia
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Arq. Bras. Cardiol. · Sep 2013
Clinical TrialMaternal restriction of polyphenols and fetal ductal dynamics in normal pregnancy: an open clinical trial.
We have recently demonstrated reversal of fetal ductal constriction after dietary maternal restriction of polyphenol-rich foods (PRF), due to its inhibitory action on prostaglandin synthesis. ⋯ The oriented restriction of third trimester maternal ingestion of polyphenol-rich foods for a period of 2 weeks or more improve fetal ductus arteriosus flow dynamics and right ventricular dimensions.
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Arq. Bras. Cardiol. · Sep 2013
P2Y12 platelet receptors: importance in percutaneous coronary intervention.
Apart from their role in hemostasis and thrombosis, platelets are involved in many other biological processes such as wound healing and angiogenesis. Percutaneous coronary intervention is a highly thrombogenic procedure inducing platelets and monocytes activation through endothelial trauma and contact activation by intravascular devices. ⋯ However, not all compounds that target the P2Y12 receptor have similar efficacy and safety profiles. Despite targeting the same receptor, the unique pharmacologic properties of each of these P2Y12 receptor-directed compounds can lead to very different clinical effects.