European heart journal. Acute cardiovascular care
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Eur Heart J Acute Cardiovasc Care · Aug 2018
Review Meta AnalysisEditor's Choice-Effects of targeted temperature management on mortality and neurological outcome: A systematic review and meta-analysis.
The purpose of this study was to conduct a systematic review, and where applicable meta-analyses, examining the evidence underpinning the use of targeted temperature management following resuscitation from cardiac arrest. ⋯ Low quality evidence supports the in-hospital initiation and maintenance of targeted temperature management at 32-36°C amongst adult survivors of out-of-hospital cardiac arrest with an initial shockable rhythm for 18-24 h. The effects of targeted temperature management on other populations, the optimal rate and method of cooling and rewarming, and effects of fever require further study.