Przegla̧d epidemiologiczny
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Actual criteria for diagnosis and classification of sepsis are presented, and the influence of an ongoing investigation of the pathogenesis of sepsis on the development of new diagnostic and therapeutic tools is discussed. Direct intervention in the innate immunity and systemic inflammatory response mechanisms seems promising therapeutic approach and some potential therapies are under development, including attempts to modulate function of innate immunity Toll-like receptors.
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Serologic confirmation is required for diagnosis of Lyme borreliosis in all the patients except those with well confirmed and typical erythema migrans (EM) lesion. In patients with articular symptoms, the primary cause of seronegativity is performing a test at a very early stage of the disease, before detectable levels of anti-Borrelia burgdorferi s.l. antibodies build up. ⋯ Secondly, insufficient antibiotic treatment of EM may halt development of humoral response without total eradication of the pathogen, which may result in the relapse of arthritis without detectable anti-B. burgdorferi s.l. antibodies for up to several months later--a rather rare phenomenon, which, however, must be taken into consideration in patients with a history of treated EM. A fe cases of seronegative Lyme arthritis not related to previous antibiotherapy have been reported, but i seems an extremely rare condition, and, if suspected, should be confirmed by histopathologic or molecular examination of the material from the affected joint.
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The health of the individuals and whole population is determined by many interrelated factors. Primary by socio-economic distal determinants which are essential for health inequalities. ⋯ The concept of investment for health is described. Principles of healthy public policy and prospects of health in all policies, Impact Assessment methodology and Health Impact Assessment are marked out.
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Case Reports
[Encephalomeningitis caused by Listeria monocytogenes in patient infected by TBE virus--case report].
The epidemiology of listeriosis is constantly changing towards higher incidence. The most endangered group of patients are people with immunodeficiency caused by coexisting diseases. In these cases listeriosis may take a very severe course. In this paper we present a case of a 76 year old female who suffered from encephalomeningitis caused by Listeria monocytogenes and additionally was infected by tick borne encephalitis virus and Borrelia burgdorferi.
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Case Reports
[Favourable course of herpes simplex encephalitis in the 37-year-old woman in 26th weeks of pregnancy].
Herpes simplex (HSV) encephalitis is a disease with a high mortality. HSV infections affect relatively young people. Characteristic neurological signs, MRI findings, PCR of cerebrospinal fluid (CSF) are useful tools in early recognition of HSV encephalitis. We present a case of HSV encephalitis with favourable course in 37-year-old woman in 26 week of pregnancy.