Zhonghua zheng xing shao shang wai ke za zhi = Zhonghua zheng xing shao shang waikf [i.e. waike] zazhi = Chinese journal of plastic surgery and burns / [Chung-hua cheng hsing shao shang wai k'o tsa chih pien chi wei yüan hui pien chi]
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Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi · Jan 1994
Comparative Study[Experimental study of antiinfection effect of topical "moist ointment" in burn wound infection].
A controversy on the therapeutic effect of topical "moist ointment" in burns has been noticed recently. An experimental study is designed for the evaluation of its antibacterial and antiinfection effect. A 20% fullthickness burn wound is produced on SD rat back, and they are seeded with 10(9) CFU of Pseudomonas aeruginosa ATCC-27853. "Moist ointment", cream base, 1% silver sulfadiazine (Ag-SD) cream or 1.2% silver norfloxacin (Ag-FLX) cream is topically applied to the burn wounds at various time interval of 10 min, 8h, 24h, and 48h, after the inoculation of Pseudomonas aeruginosa. ⋯ However, "moist ointment" and cream base do not show antibacterial effect. Bacterial counts of subeschar tissue and histopathologic study of the infected burn wounds show that more than 70% of the animals in the "moist ointment" group have invasive wound infection, and the incidence of septicemia with Pseudomonas aeruginosa is 50% as determined by blood cultures. The above mentioned results indicate that "moist ointment" has no antibacterial and anti-infection effect.