Zhonghua zheng xing shao shang wai ke za zhi = Zhonghua zheng xing shao shang waikf [i.e. waike] zazhi = Chinese journal of plastic surgery and burns / [Chung-hua cheng hsing shao shang wai k'o tsa chih pien chi wei yüan hui pien chi]
-
Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi · May 1995
[The characteristics of inhalation injury and pulmonary infection in burn patients and the influence on their mortality].
940 patients with thermal injury during the past 14 years were reviewed. Of them, inhalation injury was diagnosed in 75 patients, including 15 mild injury who all survived, 25 moderate injury, of whom 13 died with a mortality rate of 52.0% and 35 severe injury, of whom 31 died with a mortality rate of 88.6%. The data showed that 70% of burn that caused inhalation injury occurred in a closed space and 96% of which also caused facial injury. ⋯ The time and incidence of pulmonary infection in the patients with inhalation injury was earlier and higher than that in those without inhalation injury (P < 0.01). With similar burn area and age, the risk of death in the patients with inhalation injury was 17.2 times of the patients without inhalation injury (P < 0.001). Pulmonary infection further increased mortality of the patients (P < 0.001).
-
Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi · Sep 1994
["Moist burn ointment" brought about multiple systemic complications in children with burns].
From January 1990 to December 1992, twenty-one burned children, who were treated with "Moist burn ointment", were transferred to our hospital after the occurrence of invasive infection, multiple systemic complications or electrolyte disorder. The age ranged from 1 to 5 years. The total burn area ranged 5-30 per cent (mean 16.0 +/- 5.8 per cent) of the body surface area. ⋯ Of the 21 patients, 4 died. We believed that the severe infection of burn wounds, resulted from the application of "Moist burn ointment" was the main factor of causing multiple organ damage. Therefore, it is suggested that the "Moist burn ointment" should be used with great caution.
-
Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi · Jul 1994
[The role tumor necrosis factor in multiple organ dysfunction caused by bowel ischemia and reperfusion].
To explore the role of tumor necrosis factor (TNF) in the pathogenesis of multiple organ dysfunction following bowel ischemia and reperfusion, 98 rats were subjected to occlusion of the superior mesenteric artery for 45 minutes. It was found that the plasma TNF level increased rapidly after release of the clamp, peaking to 27.59 +/- 11.13 ng/ml 2 hours after reperfusion. ⋯ Furthermore, the results showed that pretreatment with monoclonal antibody to TNF-alpha could significantly lowered the plasma TNF content and notably improved the functions of various organs. This study demonstrated that release of TNF might result in systemic hypotension and remarkable damage to liver, kidneys and lungs, which contributed to the development of sepsis and multiple system organ failure following severe ischemia-reperfusion injury of the intestine.
-
Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi · Jul 1994
[Experimental study of the evaluation of efficacy of fluid replacement based on Parkland formula for burn shock].
In order to investigate the effect of fluid resuscitation of burn shock according to Parkland formula and to find out whether it leaves any damage due to hypoxia, 22 male mongrel dogs with 50% III degrees burn were divided randomly into two groups. Group 1 (14 dogs) received no fluid replacement, whereas in group 2 (8 dogs) Ringer's lactate solution was given according to Parkland formula after the injury. Swan-Ganz catheter was inserted to the pulmonary artery before burn. ⋯ However, even in these survived dogs, markedly decreased cardiac output and oxygen consumption were observed over the first 18 hours postburn. This indicated that fluid replacement according to Parkland formula can not completely correct the inadequacy of tissue perfusion, and it may leave certain damage of oxygen deficiency. Therefore, further improvement in fluid resuscitation and combined treatment for early burn shock to raise cardiac output and improve tissue oxygen delivery may be needed.
-
Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi · Jan 1994
Comparative Study[Experimental study of antiinfection effect of topical "moist ointment" in burn wound infection].
A controversy on the therapeutic effect of topical "moist ointment" in burns has been noticed recently. An experimental study is designed for the evaluation of its antibacterial and antiinfection effect. A 20% fullthickness burn wound is produced on SD rat back, and they are seeded with 10(9) CFU of Pseudomonas aeruginosa ATCC-27853. "Moist ointment", cream base, 1% silver sulfadiazine (Ag-SD) cream or 1.2% silver norfloxacin (Ag-FLX) cream is topically applied to the burn wounds at various time interval of 10 min, 8h, 24h, and 48h, after the inoculation of Pseudomonas aeruginosa. ⋯ However, "moist ointment" and cream base do not show antibacterial effect. Bacterial counts of subeschar tissue and histopathologic study of the infected burn wounds show that more than 70% of the animals in the "moist ointment" group have invasive wound infection, and the incidence of septicemia with Pseudomonas aeruginosa is 50% as determined by blood cultures. The above mentioned results indicate that "moist ointment" has no antibacterial and anti-infection effect.