Sheng li ke xue jin zhan [Progress in physiology]
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Sheng Li Ke Xue Jin Zhan · Jul 2001
Review[Analgesic mechanisms of noradrenaline in the spinal dorsal horn].
The superficial laminae of the spinal dorsal horn play important roles in nociceptive transmission and modulation. Noradrenergic fibers originated from brainstem pain-control system terminate and release noradrenaline (NA) in the superficial dorsal horn. The released NA might take part in the modulation of nociceptive transmission through the following pathways: (1) inhibits the glutamate and substance P release from primary afferent terminals; (2) increases the release of inhibitory neurotransmitters from lamina II (substantia gelatinosa) neurons. Morphological findings also raise the possibility that NA directly inhibits projection neurons in laminae I/III which convey the nociceptive information to the thalamus, thus inhibit nociceptive transmission at spinal level.
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Peripheral tissue and nerve injury lead to chronic pain symptoms, including spontaneous pain, allodynia and hyperalgesia. Sympathetic nervous system involves in pathological changes above, either through development of abnormal sympathetic function or through its effects on abnormally functioning afferent nerves, thereby to cause many neuropathic pains. This review focuses on the progress at present of sympathetic-sensory coupling and its receptors, intracellular and neural mechanisms.
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Sheng Li Ke Xue Jin Zhan · Jul 1999
Review[Neural and hemodynamic mechanisms of neurogenic pulmonary edema].
Acute pulmonary edema has been reported in man and animals with intracranial disorders, head trauma or cerebral compression. In anesthetized rats, cerebral compression produced acute, fulminating and fatal lung injury. ⋯ Pulmonary volume loading was the result of drastic decrease in aortic flow accompanying a decline in pulmonary arterial flow. The acute increase in pulmonary blood volume caused severe rises in pulmonary arterial and venous pressures leading to disruption of lung vessels.