Current opinion in neurology and neurosurgery
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The development of antiepileptic drugs has been rather slow, and this may be related partly to the regulatory requirement to show unequivocal benefit of a new agent over existing drugs. There is a need to reconsider trial protocols to achieve this objective. ⋯ Of the others, loreclezole and stiripentol (STP) are showing the highest potential for therapeutic application. Clobazam appears to be more effective than implied from earlier reports.
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Recent research on the site of action of morphine, its distribution following systemic administration and activity in a model of neuropathic pain is reviewed. Neuropeptides and pain is discussed in relation to tachykinins and their antagonists, cholecystokinin (CCK) and its antagonists and somatostatin.
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Curr Opin Neurol Neurosurg · Aug 1992
ReviewCongenital, hereditary and developmental spinal cord disease.
A number of papers have been published during 1991 in the area of congenital, hereditary and developmental spinal cord disorders, which discuss a wide range of rare spinal anomalies; there have, however, been no significant advances. The diagnosis of these disorders has been enhanced by the use of magnetic resonance imaging (MRI).