Current opinion in neurology and neurosurgery
-
Usefulness of grading systems based on non-specific features (e.g. mitosis, necrosis) is unequivocal in only certain types of astrocytomas, and their efficiency remains to be seen in oligodendrogliomas and in mixed oligo-astrocytomas. The possibility of grading ependymomas is still uncertain. Accordingly, only a small proportion of gliomas which occur in children can be reliably graded. Lack of reproducibility is a severe impediment of both current conventional and kinetic methods in the prognosis of gliomas.
-
The development of antiepileptic drugs has been rather slow, and this may be related partly to the regulatory requirement to show unequivocal benefit of a new agent over existing drugs. There is a need to reconsider trial protocols to achieve this objective. ⋯ Of the others, loreclezole and stiripentol (STP) are showing the highest potential for therapeutic application. Clobazam appears to be more effective than implied from earlier reports.
-
Recent research on the site of action of morphine, its distribution following systemic administration and activity in a model of neuropathic pain is reviewed. Neuropeptides and pain is discussed in relation to tachykinins and their antagonists, cholecystokinin (CCK) and its antagonists and somatostatin.
-
Curr Opin Neurol Neurosurg · Aug 1992
ReviewCongenital, hereditary and developmental spinal cord disease.
A number of papers have been published during 1991 in the area of congenital, hereditary and developmental spinal cord disorders, which discuss a wide range of rare spinal anomalies; there have, however, been no significant advances. The diagnosis of these disorders has been enhanced by the use of magnetic resonance imaging (MRI).