Archives internationales de pharmacodynamie et de thérapie
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Arch Int Pharmacodyn Ther · May 1980
Clonidine on the pressor response to raised intracranial pressure.
We attemptedto clarify the mechanism of the pressor response to raised intracranial pressure (ICP) in urethane-anesthetized rabbits. Intraventricular clonidine inhibited the pressor response to raised ICP, and intraventricular phentolamine antagonized the inhibitory effect of clonidine on the pressor response. ⋯ Intraventricular clonidine inhibited the pressor response that could be observed in the reserpine-treated rabbits following the intraventricular norepinephrine. These results suggest that the central sympathetic neurons play an important role in producing the pressor response to raised ICP.