Archives internationales de pharmacodynamie et de thérapie
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Arch Int Pharmacodyn Ther · Nov 1993
Comparative StudyEffects of hemorrhage on regional cerebral blood flow in awake and in isoflurane-anesthetized rats.
During hemorrhage, redistribution of cerebral blood flow may occur. We compared the effects of hemorrhage on regional cerebral blood flow in awake rats and in rats anesthetized with 1% or 2% isoflurane. In half of each group, regional cerebral blood flow was measured without hemorrhage. ⋯ However, the absolute value of the cortical flow was higher in the awake animals than in the isoflurane groups. Our experiment demonstrated that hemorrhage decreased the regional cerebral blood flow. However, it did not alter the redistribution of the cerebral blood flow in awake animals nor in the animals anesthetized with isoflurane.