Journal of neurology
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Journal of neurology · Mar 2004
Comparative StudyEffects of subthalamic nucleus stimulation on parkinsonian dysarthria and speech intelligibility.
Subthalamic stimulation is known to improve tremor, akinesia and rigidity in Parkinson's disease. However, other signs such as hypophonia and swallowing disorders can be relatively resistant to this technique. The effect on dysarthria remains unclear. ⋯ In conclusion, surgery had weak effects on dysarthria. Intelligibility can be worsened, especially in the on-drug condition. Thus, adaptation of the stimulation parameters can be difficult.
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Journal of neurology · Mar 2004
Comparative StudyPrevalence of Parkinson's disease and other types of Parkinsonism. A door-to-door survey in Bidasoa, Spain.
To assess the prevalence of Parkinson's disease and parkinsonism in two Spanish populations (Irun and Hondarribia, Bidasoa Region) and to compare the results with those of similar surveys. ⋯ These prevalence rates are similar than those found in studies made in other European countries. The prevalence of both Parkinson's disease and other types of parkinsonism increased with age, with no significant differences between men and women.
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Journal of neurology · Mar 2004
Comparative StudyWater content and myelin water fraction in multiple sclerosis. A T2 relaxation study.
Measurements of the T2 decay curve provide estimates of total water content and myelin water fraction in white matter in-vivo, which may help in understanding the pathological progression of multiple sclerosis (MS). ⋯ NAWM in MS has a higher water content and lower myelin water fraction than control white matter. The cause of the myelin water fraction decrease in NAWM could potentially be due to either diffuse edema, inflammation, demyelination or any combination of these features. We present a simple model which suggests that myelin loss is the dominant feature of NAWM pathology.