Journal of neurology
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Journal of neurology · Mar 2006
Randomized Controlled Trial Comparative Study Clinical TrialNo adrenergic sensitization of afferent neurons in painful sensory polyneuropathy.
The aim of the present study was to determine (1) if an adrenergic sensitivity of afferent neurons is present in patients with painful polyneuropathy as compared with non-painful polyneuropathy and (2) if there is a correlation between adrenergic sensitisation and the severity of afferent and sympathetic small fiber damage. ⋯ The results do not support the assumption that in painful polyneuropathies afferent neurons acquire an adrenergic sensitivity after nerve injury and that adrenergic stimulation leads to an exacerbation of spontaneous pain and thermal and mechanical hyperalgesia.