Journal of neurology
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Journal of neurology · Apr 2008
Clinical TrialBotulinum toxin type-B improves sialorrhea and quality of life in bulbaronset amyotrophic lateral sclerosis.
Sialorrhea is a disabling problem in bulbaronset amyotrophic lateral sclerosis (ALS). Botulinum toxin (BTX) type A and B have been proposed as alternatives to traditional treatments. ⋯ Anatomic guided BTX type B injections seem effective and safe to treat sialorrhea in bulbar-onset ALS.
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Subarachnoid haemorrhage (SAH) is less frequent than ischaemic stroke or intracerebral haemorrhage, but has a high public health relevance because it can affect young and middle-age adults, has considerable mortality and morbidity, it is treatable and preventable. SAH is traditionally a topic for neurosurgeons. ⋯ We review the recent advances in the clinical and diagnostic aspects of SAH and in the genetics of intracranial aneurysms. A systematic review of the treatment of SAH and grading of the available evidence is included.