Journal of neurology
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Journal of neurology · Jun 2021
ReviewA review of pathophysiology and neuropsychiatric manifestations of COVID-19.
The outbreak of coronavirus disease 2019 (COVID-19) has become one of the most serious pandemics of the recent times. Since this pandemic began, there have been numerous reports about the COVID-19 involvement of the nervous system. There have been reports of both direct and indirect involvement of the central and peripheral nervous system by the virus. ⋯ The neurological manifestations of the COVID-19 are varied and the data about this continue to evolve as the pandemic continues to progress.
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Journal of neurology · Jun 2021
Guillain-Barré syndrome in patients treated with immune checkpoint inhibitors.
Guillain-Barré syndrome (GBS) induced by immune checkpoint inhibitors (ICIs) has been occasionally reported in randomized clinical trials (RCTs), but the post-marketing data are quite limited. This study aimed to comprehensively examine GBS events secondary to ICI treatments in the real-world patients based on the Food and Drug Administration Adverse Event Reporting System (FAERS). ⋯ As complements to the safety data from RCTs, the current pharmacovigilance research helps establish a more detailed overview of ICI-related GBS, which facilitates the understanding of this rare adverse drug effect.