Anaesthesia, critical care & pain medicine
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Anaesth Crit Care Pain Med · Feb 2020
Observational StudyT regulatory cells activation and distribution are modified in critically ill patients with acute respiratory distress syndrome: A prospective single-centre observational study.
Acute respiratory distress syndrome (ARDS) is a common and fatal inflammatory condition. Whether T regulatory cells (Tregs) are beneficial or detrimental remains controversial, and longitudinal studies are lacking. Phenotyping of Tregs activation markers has been poorly reported. We aimed to evaluate quantitative and functional alterations in blood and bronchoalveolar Treg phenotype of ARDS patients. ⋯ Quantitative and functional alterations in Treg phenotype were observed in patients with ARDS. Whether rebalancing Tregs phenotype with therapeutic interventions would be beneficial deserves further investigations.
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Anaesth Crit Care Pain Med · Feb 2020
Review Practice GuidelineManagement of liver failure in general intensive care unit.
To produce French guidelines on Management of Liver failure in general Intensive Care Unit (ICU). ⋯ Substantial agreement exists among experts regarding numerous strong recommendations on the optimum care of patients with liver failure in general ICU.
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Anaesth Crit Care Pain Med · Feb 2020
ReviewAnaesthesia-specific checklists: A systematic review of impact.
Checklists are recognised as powerful tools to prevent avoidable errors in high-reliability organisations. In healthcare, the perioperative area has been a leading field in the development of a wide range of checklists. However, clinical literature on this subject is still sparse and heterogeneous, producing results that are sometimes conflicting. ⋯ Beyond the WHO surgical time-out, anaesthesia-specific checklists have been shown to be useful for provider handoffs, emergencies, and routine anaesthesia procedures. However, literature on anaesthesia-specific checklists is still limited and very heterogeneous. More large-scale studies are necessary to identify an ideal anaesthesia checklist and its most appropriate implementation method.