Acta medica Scandinavica
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Acta medica Scandinavica · Jan 1981
Comparative StudyEffect of peroral thiamine treatment on thiamine contents and transketolase activity of red blood cells in alcoholic patients.
The thiamine contents, transketolase activity and "thiamine diphosphate effect" (TDP effect) of the transketolase activity were measured in the blood of alcoholic patients during withdrawal, before and after thiamine administration (50 mg) for 10 days. The results were compared with those of healthy volunteers. The alcoholic patients showed significantly lower thiamine contents, lower transketolase activity and higher TDP effect in the blood than the healthy volunteers. ⋯ When thiamine was administered in a dose of 50 mg for 10 days, the TDP effect normalized. The transketolase activity and thiamine contents, however, were only slightly increased, probably due to the fact that the apo-enzyme content and the thiamine-binding capacity were lower in the blood of the alcoholics. Thus the TDP effect seems to reflect the relative biochemical deficiency while transketolase activity and thiamine contents seem to be dependent on the amount of apo-enzyme and on the thiamine-binding capacity as well as the degree of thiamine deficiency.
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Acta medica Scandinavica · Jan 1981
Oxypurine release in cardiac disease. An indicator of general hypoxia in patients with cardiac arrest.
The excretion of hypoxanthine-xanthine and uric acid in urine and the concentrations in peripheral venous blood were determined in nine patients with cardiac arrest due to acute myocardial infarction (AMI), in ten control patients with AMI without cardiac arrest and in nine with angina pectoris. The patients with cardiac arrest showed a 6-fold increase in urinary excretion of hypoxanthine-xanthine 0-2 hours after cardiac arrest. ⋯ The urinary excretion of hypoxanthine-xanthine increases considerably in connection with reversible cardiac arrest, indicating general tissue hypoxia. No relationship could be found between the duration of cardiac arrest and the increased hypoxanthine-xanthine excretion in the urine.
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Acta medica Scandinavica · Jan 1981
Case ReportsHereditary hemorrhagic telangiectasia (Osler-Weber-Rendu disease) complicated by pulmonary arteriovenous fistula and brain abscess.
A man who developed two brain abscesses was later found to have hereditary hemorrhagic telangiectasia with a pulmonary arteriovenous fistula. Brain abscess is a known complication of pulmonary arteriovenous fistulas. About 15% of patients with hereditary hemorrhagic telangiectasia develop such a fistula during their lives. Surgical resection of pulmonary arteriovenous fistulas is recommended because of the risk of severe neurological sequelae.