Voprosy onkologii
-
The effect of various light regimens--standard, 12 hrs light:12 hrs darkness, natural lighting in the North-West of Russia and constant illumination--on homeostasis, life span and spontaneous tumorigenesis has been studied in male rats. It was shown that constant exposure or natural lighting involved accelerated aging as evaluated by coefficient of homeostatic stability and survival curves shifting to the left. Constant illumination was followed by a significantly faster spontaneous tumorigenesis as compared with standard lighting. Nocturnal administration of melatonin with drinking water (10 mg/l) prevented the adverse effects of constant and natural lighting on homeostasis and inhibited spontaneous tumorigenesis, particularly, that in the hemopoietic system.
-
Review Historical Article
[Cancer control studies at the N.N. Petrov Research Institute of Oncology].
-
Surgery for brain metastases is an effective treatment for most cancer patients. It involves low post-operative lethality (2.9%) and causes neurological symptoms to regress in most patients. 12-month survival occured in 48.5%, 5 years--10.8%; mean survival duration with good quality of life--11.8 months. Survival basically depended on tumor pattern, metastases to other organs, multiple foci in the brain and habitus.