The Journal of investigative dermatology
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J. Invest. Dermatol. · Jun 2007
Comparative Study Clinical TrialQuality-of-life outcomes of treatments for cutaneous basal cell carcinoma and squamous cell carcinoma.
Quality of life is an important treatment outcome for conditions that are rarely fatal, such as cutaneous basal cell carcinoma and squamous cell carcinoma (typically called nonmelanoma skin cancer (NMSC)). The purpose of this study was to compare quality-of-life outcomes of treatments for NMSC. We performed a prospective cohort study of 633 consecutive patients with NMSC diagnosed in 1999 and 2000 and followed for 2 years after treatment at a university-based private practice or a Veterans Affairs clinic. ⋯ There was no difference in the amount of improvement after excision or Mohs surgery. For example, mean Skindex Symptom scores improved 9.7 (95% CI: 6.9, 12.5) after excision, 10.2 (7.4, 12.9) after Mohs surgery, and 3.4 (-0.9, 7.6) after ED&C. We conclude that, for NMSC, quality-of-life outcomes were similar after excision and Mohs surgery, and both therapies had better outcomes than ED&C.
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J. Invest. Dermatol. · Jun 2007
Comment ReviewOpioids and the skin: "itchy" perspectives beyond analgesia and abuse.
Opioids are intimately linked to central pain inhibition and their abuse potential. Thus, peripheral opioid receptors in the skin have been studied initially with a focus on their peripheral analgesic properties. Recent results, however, clearly indicate that opioids play a specific role in skin homeostasis by modulating keratinocyte differentiation, wound healing, and inflammatory responses.