Zentralblatt für Neurochirurgie
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The case of a 36-year-old patient with an intramedullary neurinoma of the thoracic spine without Recklinghausen's disease is presented. The intramedullary neurinoma is a very rare condition. Only 33 cases have been reported in the literature. ⋯ The case described here was diagnosed by magnetic resonance imaging (MRI). Histologically, the tumor showed all features characteristic of a neurinoma. Postoperatively, the patient is nearly without complaints.
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Zentralbl. Neurochir. · Jan 1990
Effect of gammahydroxybutyrate on intracranial pressure, mean systemic arterial pressure and cerebral perfusion pressure in experimentally induced brain oedema of the rat.
In the treatment of raised intracranial pressure (ICP) an agent is needed which can similarly reduce ICP and protect the brain without reducing systematic arterial pressure and cerebral perfusion pressure. Gammahydroxybutyrate (GHB) decreases cerebral metabolic requirement of oxygen (CMRO2) and glucose utilization rate. ⋯ The decrease in intracranial pressure is not due to a reduction in the mean systemic arterial pressure, but GHB does reduce the ICP while increasing mean systemic arterial pressure and cerebral perfusion pressure. GHB may be a useful adjunct to neurosurgical therapy in controlling elevated ICP.