Primary care
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The results of pancreas transplantation at the University of Minnesota according to technique, donor source, and immunosuppressive therapy are discussed. Preliminary evidence suggests that not only prevention but reversal of lesions resulting from diabetes may be possible with pancreas transplantation.
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The medical emergency of diabetic ketoacidosis is a particular problem for children with insulin-dependent diabetes because it is frequently associated with their initial presentation. Subsequent episodes can be prevented with proper use of personal glucose monitoring. The pathophysiology and diagnosis of diabetic ketoacidosis are reviewed, and a framework for the management of this complication in children is provided.
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Case Reports
Etiology and classification of diabetes in children. Practical genetics and prognosis counseling.
The genetic, viral, and autoimmune factors that may play a role in causing insulin-dependent diabetes are explored. The author presents guidelines for genetic counseling of families with diabetic children. Case histories illustrate various atypical presentations of diabetes in children, and help the clinician in diagnosing and managing the borderline diabetic.
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Case Reports Comparative Study
Clinical pancreas and islet transplantation. Part 1: registry statistics and an overview.
Pancreas transplantation has evolved into a safe and moderately successful procedure for the treatment of selected patients whose diabetic complications are more serious than the potential side effects of chronic immunosuppression. Islet transplantation, however, remains largely unsuccessful. An overview of pancreas and islet transplantation experience worldwide is presented. Results of transplants according to association with kidney transplants, technique, immunosuppression, and organ preservation are evaluated.