Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
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Sichuan Da Xue Xue Bao Yi Xue Ban · Apr 2003
[Study on the gene knockout model mice of Duchenne muscular dystrophy].
With a view to further experimental studies on Duchenne muscular dystrophy (DMD), we investigated the motor function, serum creatine kinase (CK) level and pathological characteristics of muscular tissue in C57, mdx, dystrophin/utrophin gene double knockout (dko)mice. ⋯ Compared with mdx mouse, dko mouse is in a more serious illness state which is nearer to the natural state of DMD. Therefore, dko mouse is a more ideal model for studying the praxiology of DMD.