Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition
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Sichuan Da Xue Xue Bao Yi Xue Ban · Jan 2008
[Effects of preemptively injected intrathecal lornoxicam on behavior and c-fos protein expression of rat with formalin hurting].
The objective of this study was to investigate an antinociceptive effect of preemptive intrathecal lornoxicam on behavior and expression of c-Fos protein in the spinal cord of the formalin hurting rats. ⋯ Pre-intrathacal lornoxicam can successfully inhibit nociceptive behavior and c-Fos expression in spinal dorsal horn of formalin test rats. This effect is correlated with the dosage of lornoxicam and has ceiling phenomenon.
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Sichuan Da Xue Xue Bao Yi Xue Ban · Nov 2007
[Interrelationship between change of cAMP responsive element binding protein (CREB) or N-methyl-D-aspartate receptor (NR1) expressing in hippocampus and impairment of learning and memory after epilepsy].
The changes of transcription factors CREB and glutamate receptor N-methyl-D-aspartate (NMDA) receptor subtype NR1 expressing in hippocampus and the relationship between CREB or NR1 expression change and learning or memory deficit after epilepsy. Exploring the role of CREB and NR1 in impairment of cognitive function after epilepsy. ⋯ The change of learning and memory after epilepsy is related to the expression of NR1 and CREB in hippocampus. The epilepsy seizures to SE and CEP rats could result in the impairment of learning and memory, and be followed by the decreases in expression of NR1 and CREB mRNA and level of CREB protein. It shows that NR1 and CREB may be involved in the pathophysiological process of learning and memory deficit.
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Sichuan Da Xue Xue Bao Yi Xue Ban · Nov 2007
[Fentanyl hypnotic interaction with emulsified isoflurane].
To explore the effect of fentanyl on 50% effective dose (ED50) of emulsified isoflurane for hypnosis and to define the type of interaction between fentanyl and emulsified isoflurane during rat hypnosis. ⋯ Fentanyl enhances the hypnotic effect induced by emulsified isoflurane. The administration of associating fentanyl with emulsified isoflurane produces a synergistic effect on rat hypnosis.
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Sichuan Da Xue Xue Bao Yi Xue Ban · Sep 2007
Randomized Controlled Trial[Verapamil effect and influence on postoperative epidural analgesia and cell factors TNFalpha, IL-6 and IL-2].
To evaluate the nonopioid analgesic drug effect and influence on serum cytokine and postoperative epidural analgesia. ⋯ Epidural verapamil analgesia can reduce analgesic cost, and the effective epidural analgesia can reduce the postoperative distress.
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Sichuan Da Xue Xue Bao Yi Xue Ban · Sep 2007
[Effect of decreased GSH on sensitivity of breast cancer cells to ADM].
Glutathione(GSH) maintains an optimum cellular redox potential. Elevated levels of GSH render some types of cancer cells resistant against anti-cancer drugs. The aim of this study was to determine the effect of a thiol-depleting agent, diethylmaleate (DEM), on the sensitivity of human breast cancer cells to ADM. ⋯ The depletion effect of DEM on the intracellular GSH could be enhanced by ADM and such depletion may be involved in the changes of the sensitivity of MCF/7 cells to ADM.