Fortschritte der Medizin
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Fortschritte der Medizin · Jul 1994
Randomized Controlled Trial Multicenter Study Comparative Study Clinical Trial[Treatment of tumor pain with flupirtine. Results of a double-blind study versus tramadol].
In a multicentric double-blind trial, flupirtine was compared with tramadol in the treatment of cancer pain. ⋯ Initially comparable in the two groups, pain was more markedly reduced after four weeks of treatment with flupirtine than after tramadol, the need for additional analgesic drugs also being less in the flupirtine group. The final general assessment by the attending doctors of the results achieved was "good" to "very good" in 63% of the patients on flupirtine, and in 46% of those on tramadol. Undesired effects were observed in 6% of the flupirtine patients and in 19% of those taking tramadol.
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Fortschritte der Medizin · Jul 1994
Review[Alcoholic delirium--a potentially life-threatening condition].
Full-blown alcoholic delirium is characterised by the symptoms of an exogenous psychosis and signs of vegetative dysregulation. Organic brain disease may initiate its development. The pathogenesis of the condition remains hypothetical. ⋯ This, together with improvements in intensive medical care, has reduced the mortality rate to 3 to 8%. Concomitant organic diseases may complicate and prolong the condition. A defective state is a possible outcome.