Scandinavian journal of plastic and reconstructive surgery
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Scand J Plast Reconstr Surg · Jan 1985
Effects of cooling after scald injury to a dorsal skin fold of mouse.
Shaved trunk skin folds of hairy mice were scalded for 20 s by water immersion. In one set of experiments the effect of increasing burn temperature (51 degrees C-60 degrees C) was studied, in another the folds were first scalded at 51 degrees C-54 degrees C and then immediately cooled for 30 min in 8 degrees C water. Animals were killed 2 h and 4 days postburn. ⋯ Histologically, the tissues seemed well preserved at 2 h after 51 degrees C scalds, whereas cell damage was obvious and increasingly pronounced after greater than or equal to 53 degrees C burns. After 52 degrees C burns a mixed picture emerged. A similar microscopic pattern was seen at 4 days; 51 degrees C specimens were undamaged, some 52 degrees C and all greater than or equal to 53 degrees C were necrotic.(ABSTRACT TRUNCATED AT 250 WORDS)