British heart journal
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British heart journal · Nov 1994
Randomized Controlled Trial Clinical TrialReheparinisation requirements after cardiopulmonary bypass in patients treated with aprotinin.
To determine reheparinisation requirements following protamine neutralisation after the discontinuation of cardiopulmonary bypass in a group of patients receiving "low dose" aprotinin compared with a control group. ⋯ Heparin requirements were nearly doubled in patients treated with aprotinin, who required reheparinisation for up to one hour after protamine. This relative "heparin resistance" cannot be explained by the presence of excessive protamine. Aprotinin may be a substrate for the N-carboxypeptidase that destroys protamine, thus indirectly enhancing and prolonging the activity of protamine.
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British heart journal · Jul 1993
Randomized Controlled Trial Clinical TrialAmiodarone prophylaxis for tachycardias after coronary artery surgery: a randomised, double blind, placebo controlled trial.
Arrhythmias are a common cause of morbidity after cardiac surgery. This study assessed the efficacy of prophylactic amiodarone in reducing the incidence of atrial fibrillation or flutter and ventricular arrhythmias after coronary artery surgery. ⋯ The incidence of clinically significant tachycardia was reduced by amiodarone. The ventricular response rate was slowed in supraventricular tachycardia, but the induction of bradycardia may preclude the routine use of amiodarone for prophylaxis.
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British heart journal · Jun 1993
Randomized Controlled Trial Clinical TrialAspirin does not improve early arterial patency after streptokinase treatment for acute myocardial infarction.
To investigate the hypothesis that the magnitude of the life saving effect of aspirin in the second international study of infarct survival (ISIS-2) trial cannot be explained solely by prevention of late reocclusion of the infarct related artery. The aim of this study was to discover whether or not aspirin in combination with streptokinase had an adjuvant thrombolytic effect. ⋯ The magnitude of the life saving effect of aspirin remains unexplained. Further investigation is needed into the mechanism of action of antiplatelet treatment in relation to thrombolytic treatment.
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British heart journal · Feb 1992
Randomized Controlled Trial Comparative Study Clinical TrialDetermination of cardiac output by an angle and diameter independent dual beam Doppler technique in critically ill infants.
To compare cardiac output measurements in critically ill infants by the dual beam Doppler and thermodilution techniques. ⋯ The dual beam Doppler technique was shown to have promise for the non-invasive determination of cardiac output in critically ill infants.
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British heart journal · Apr 1984
Randomized Controlled Trial Clinical TrialEffect of metoprolol on chest pain in acute myocardial infarction.
A total of 1395 patients aged 40 to 74 years were included in a double blind trial with the beta 1 selective blocker metoprolol in suspected acute myocardial infarction. Metoprolol was given intravenously (15 mg) as soon as possible after admission to hospital followed by 200 mg daily for three months. A placebo was given in the same manner. ⋯ The estimated duration of pain was shorter in the metoprolol group than in the placebo group. These effects were related to the initial heart rate, the initial systolic blood pressure, and the final site of the infarct as determined electrocardiographically. Thus metoprolol given in the acute phase of suspected or definite myocardial infarction appears to reduce the severity of chest pain.