Zhonghua nei ke za zhi
-
Zhonghua nei ke za zhi · Nov 1992
[Factors influencing carboxyhemoglobin kinetics in inhalation lung injury].
Anesthetized dogs were ventilated with 1% carbon monoxide (CO) in air for 10 minutes to produce CO poisoning and then with room air (n = 5) or pure oxygen (n = 5) for 3 hours as control. Acute lung injury was produced by intratracheal injection of 0.1 N HCl (2 ml/kg) 30 minutes before CO poisoning in another 10 experimental dogs. Arterial blood gas and carboxyhemoglobin (COHb) were monitored before and after CO poisoning. ⋯ No significant correlation was found between T 1/2 beta and Qs/Qt in the injured dogs ventilated with air or oxygen. A negative linear relationship was found between T 1/2 beta of COHb elimination and the pre-CO-poisoning PaO2 (r = -0.98, P < 0.005) in the injured dogs treated with oxygen. The data suggest that hypoxemia may represent the underlying mechanism of altered COHb kinetics in acute inhalation lung injury.