Zhonghua nei ke za zhi
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Zhonghua nei ke za zhi · Jul 2004
[The changes in effective local blood perfusion and compensatory ventilation in different lung areas of acute respiratory distress syndrome rabbits model].
To discuss the mechanism of severe hypoxemia that induced with acute respiratory distress syndrome (ARDS) by way of observing the effective local blood perfusion in different lung areas of ARDS rabbits. ⋯ We indicated that the one of the main mechanisms of severe hypoxemia in ARDS might be caught by the shunt between pulmonary artery and pulmonary vein just like physiological right to left shunt, which caused severe ventilation/perfusion disturbance. Both low tidal volume ventilation + PEEP and prone position + low tidal volume ventilation + PEEP had good effects on ameliorating local blood perfusion, and the effects of ventilation mode of prone position + low tidal volume ventilation +PEEP might be better.