Zhonghua nei ke za zhi
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Zhonghua nei ke za zhi · Oct 2006
[The role of CD4+ CD25+ T cell and FOXP3 in hsot acute graft rejection].
To explore the relationship among CD4+ CD25+ regulatory T cell, the expression of FOXP(3) mRNA levels of donor bone marrow (BM) and graft versus host disease (GVHD) in allogeneic hematopoietic stem cell transplantation (allo-HSCT). ⋯ (1) Donor-type CD4+CD25+ immune regulatory T cell level was related to recipient II-IV aGVHD. Up-grade donor-type CD4+CD25+ immune regulatory T cell level could reduce the incidence of aGVHD. (2) Donor BM FOXP(3) transcripts were detected in patients without serious aGVHD after transplantation.