Zhonghua nei ke za zhi
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Zhonghua nei ke za zhi · Feb 2021
[The correlation of plasma thrombomodulin plasminogen activator inhibitor-1 and endothelial cell injury in septic patients].
To study the correlation of plasma thrombomodulin (TM), plasminogen activator inhibitor-1 (PAI-1) and endothelial cell injury in septic patients. A total of 100 septic patients were enrolled from February 2017 to February 2019 in Intensive Care Unit (ICU), Union Jiangbei Hospital, Huazhong University of Science and Technology. Subjects were divided into two groups including 50 patients with septic shock and 50 patients with only sepsis. ⋯ Correlation analysis suggested that cEPCs, ESM-1 and vWF were positively correlated with TM and PAI-1 (r=0.561, 0.576, P<0.05;r=0.558, 0.603, P<0.05;r=0.677, 0.692, P<0.05). In conclusion, plasma TM and PAI-1 are closely related to the severity of endothelial cell injury in patients with sepsis. The more serious the damage of endothelial cells is, the higher the TM, PAI-1,cEPCs,ESM-1 and vWF levels are, which could be criterion for treatment evaluation.