Zhonghua nei ke za zhi
-
Zhonghua nei ke za zhi · Nov 2014
[Bortezomib-based induction therapy followed by autologous hematopoietic stem cell transplantation in multiple myeloma].
To evaluate the short-term and long-term effect of novel agents followed by autologous hematopoietic stem cell (ASCT) in Chinese multiple myeloma(MM) patients in order to find out the optimal therapeutic regimen for transplant-eligible patients. ⋯ Bortezomib-based therapy followed by ASCT is the first line therapy for transplant-eligible MM patients. Patients with different types of M protein require different induction regimens. Maintenance is beneficial to patients after ASCT, no matter whether a CR is reached or not. Patients with CR after induction or ASCT tend to have longer survival.
-
Zhonghua nei ke za zhi · Oct 2014
[Losartan modulates T helper type 1 cells and T helper type 17 cells-mediated responses in a mouse model of lipopolysaccharide-induced acute lung injury].
To assess the effect of losartan, angiotensin II receptor type 1 (AT1) receptor antagonist, on the pulmonary T helper (Th) cell polarization response in acute lung injury (ALI) mice. ⋯ Losartan has a protective effect on LPS-induced ALI, which may be partly dependent on suppressions of Th1 and Th17 polarization response.
-
Zhonghua nei ke za zhi · Oct 2014
[The effects of Peking Union Medical College Hospital Critical Ultrasonic Management scheme on the etiological diagnosis of dyspnea and/or hemodynamic instability in ICU patients].
To investigate the effects of Peking Union Medical College Hospital (PUMCH) Critical Ultrasonic Management (PCUM) scheme on the etiological diagnosis and treatment decisions for the patients with dyspnea and/or hemodynamic instability in ICU. ⋯ The PCUM scheme is associated with short time to preliminary diagnosis and high diagnostic accuracy and could improve the treatment for patients with dyspnea and/or hemodynamic instability.
-
Zhonghua nei ke za zhi · Oct 2014
[The value of corneal confocal microscopy in diagnosing early small fibre neuropathy].
To explore the diagnostic value of corneal confocal microscopy in the early small fibre neuropathy (SFN). ⋯ CCM is a new and sensitive noninvasive clinical technique that may be used to detect early small fibre nerve damage in patients with SFN.
-
Zhonghua nei ke za zhi · Sep 2014
[Increased risk of severe acute graft-versus-host disease in low body mass index patients undergoing haploidentical allogeneic stem cell transplantation].
To investigate the impact of body mass index (BMI) before transplantation on clinical outcomes of haploidentical allogeneic stem cell transplantation (allo-HSCT). ⋯ Our findings demonstrate a correlation between pre transplant BMI and clinical outcome post-transplant. Low BMI was associated with increased risk of severe acute GVHD in leukemia patients receiving haploidentical allo-HSCT. Meticulous supportive care pre-transplantation is required for low BMI patients.